trevor cooney out of boundsSyracuse survived Gonzaga Friday night, but it wasn’t without controversy. The Orange, which rallied to overcome a five-point deficit late, almost lost in heartbreaking fashion. A phantom out-of-bounds call was at the center of the storm.Gonzaga, trailing 61-60, had a chance to take the lead with 20 seconds to play, but an errant pass from Josh Perkins wound up in the hands of SU’s Trevor Cooney. Cooney, upon collecting the ball, did all he could to keep his feet inbounds.Cooney, however, was whistled out of bounds. As you’ll see below, it was a bad call.Channeling Cooney’s Balance @bballbreakdown #MarchMadness @AdamZagoria, @espn, @GregAnthony50 https://t.co/7LvScmvE9P— BBiomechanics (@BBiomechanics) March 26, 2016Yep, he’s in, what a play by Cooney. #Syracuse pic.twitter.com/wG4pfaReio— XFINITY Sports (@XFINITYSports) March 26, 2016Let’s review how much time is left.OK, now let’s make the wrong call.— Darren Rovell (@darrenrovell) March 26, 2016#cooney was #inbounds #Sweet16 #Syracuse wooooooo pic.twitter.com/tZhkMHjAnw— Grove Street (@Grove_Street2x) March 26, 2016Tyler Lydon blocked the Bulldogs’ shot on the ensuing possession, and after two Lydon free throws, the Orange emerged victorious anyway. They’ll next get UVA in an all-ACC Midwest region showdown.
Advertisement With over 71 million views, “Carmilla” has been viewed in 193 countries and translated into over 20 languages, with more than half the views coming from outside North America. Viewers of this scripted digital series are 91% female and 9% male, with 48% of those viewers in the 18-24 demo, according to YouTube analytics. Fans of the series, who refer to themselves as “Creampuffs” after a line in the series, have catapulted “Carmilla” leads Elise Bauman and Natasha Negovanlis to international stardom; most recently, Bauman was awarded the Fan’s Choice Award by the Academy of Canadian Cinema & Television at the 2018 Canadian Screen Awards, an award that co-star Negovanlis won the year prior.“Carmilla” is created and produced by Toronto-based Shaftesbury, in association with U by Kotex®, A Kimberly-Clark company, as executive producer, and was co-created and written by award-winning playwright Jordan Hall, and directed by Spencer Maybee. The series puts a modern spin on the cult gothic vampire novella by Joseph Sheridan Le Fanu, meshing the vlog aesthetic with scripted storytelling as it follows the adventures of university student Laura (Bauman), whose world is turned upside-down after a vampire (Negovanlis) moves into her dorm room.Season One launched in August 2014, Season Two in June 2015, and the third and final season in September 2016, for a total of 108 x 5 minute episodes. The series boasts one of the most engaged fandoms in the world, particularly with the global queer community, with nearly 500,000 fans across its official social accounts on YouTube, Twitter, Tumblr, Instagram, Facebook, and YouNow.Due to overwhelming fan demand, Shaftesbury announced in 2016 that it would extend the series into a feature-length movie. “The Carmilla Movie” premiered in fall 2017, playing for one night only at Cineplex theatres across Canada, before making its world television premiere on Hollywood Suite.“Carmilla” has been recognized with numerous national and international nominations and awards including the Streamy Awards, the Webby Awards, the Shorty Awards, and the Canadian Screen Awards. Shaftesbury Sales Company holds worldwide distribution rights for the series and film.About MIPTV – MIPTV (9-12 April 2018, Cannes) is the flagship and leading global TV and digital content market. Each April, over 10,000 professionals from across the international TV and digital entertainment ecosystem connect to launch and discover new content, forge partnerships, negotiate financing and distribution agreements, find co-production opportunities and explore the latest trends.MIPTV is preceded by the biggest weekend in unscripted content (7-8 April 2018), comprising MIPDoc, the world’s largest screenings library, conference and co-production marketplace for the factual community, and MIPFormats, the discovery showcase for the global formats community. www.miptv.comAbout Shaftesbury – Shaftesbury is an award-winning creator and producer of original content for television, film, digital, and brands. Shaftesbury’s current slate includes 11 seasons of Murdoch Mysteries for CBC, UKTV, and ITV STUDIOS Global Entertainment, detective drama Frankie Drake Mysteries for CBC and UKTV, and two seasons of critically acclaimed thriller series Slasher for Netflix. Shaftesbury’s digital arm produces original digital, convergent, and branded entertainment projects including the global phenomenon Carmilla, scripted comedy Upstairs Amy for Walmart and Interac®, supernatural drama Inhuman Condition, and the Slasher VR app for iOS, Android, and Oculus Rift. Shaftesbury’s branded entertainment division drives profitable engagement with millennials using scripted series, turning brands into executive producers. Recent brand partners include Walmart, Interac®, U by Kotex®, and RBC. LEAVE A REPLY Cancel replyLog in to leave a comment Advertisement Facebook Paris – MIPTV has chosen to give its Brand Content of the Year Award to Kimberly-Clark’s global phenomenon “Carmilla”, a branded entertainment digital series that has evolved to include a feature film, book deal, and primetime series in development, becoming a brand in its own right.The flagship global TV and digital content market, MIPTV takes place in Cannes, France from 9-12 April 2018. The 2018 Brand Content of the Year Award will be presented during the “Carmilla” Keynote Showcase that will take place at noon on Wednesday 11 April in the Auditorium Debussy.The “Carmilla” Showcase presents a new approach to producing original scripted content. Shaftesbury, the producers behind this successful brand, is an award-winning creator of scripted content for TV, film, and digital, and have become leaders in branded entertainment. Shaftesbury CEO Christina Jennings and SVP of Branded Entertainment Kaaren Whitney-Vernon will discuss their successes in partnering with global brands to create scripted series that have garnered both critical acclaim and international fandoms. Kimberly-Clark will accept the Brand Content of the Year award and offer insights into how “Carmilla” has driven engagement with consumers and global sales. Login/Register With: Advertisement Twitter
By Dr. Ananya Mandal, MDJan 15 2019A survey from 2018 had found that 2.1 million students from middle and high schools have smoked marijuana at least once. A new study looked at the effects of marijuana or cannabis on the brains of adolescents.The results of the study were published in the latest issue of the Journal of Neuroscience this week. The researchers were alarmed to find that marijuana or cannabis can affect the teenage brains after even a single use.The team of researchers looked at the brains of 46 fourteen year old students from England, Ireland, France and Germany. They noted that those of the participants who had smoked just one or two joints had a higher brain volume compared to the teenagers that did not. The gray matter in these teenagers was larger. This area of the brain is altered with maturity of the brain. The National Institutes of Health (NIH) says that with aging the brain size normally decreases. The researchers have said that this study shows that marijuana could affect the normal aging process of the brain.Hugh Garavan, lead author of the study and a professor of psychiatry at the University of Vermont School of Medicine, explained that the cortical region of the brain of these teenagers were “going through a process of thinning.” He said that the normal maturation and pruning process of the brain was being affected by the marijuana. “So, one possibility is that the cannabis use has disrupted this pruning process, resulting in larger volumes (i.e., a disruption of typical maturation) in the cannabis users. Another possibility is that the cannabis use has led to a growth in neurons and in the connections between them,” he said.Related StoriesPosterior parietal cortex plays crucial role in making decisions, research showsNeural pathways explain the relationship between imagination and willingness to helpWearing a hearing aid may mitigate dementia riskGaravan said in a statement, “Most people would likely assume that one or two uses (joints) would have no impact, so we were curious to study this — and especially to investigate if first uses may actually produce brain changes that affect future behavior like subsequent use.”The team accepts that this is a small study with a small number of participants and thus the results should be interpreted carefully. Larger and long term studies are needed to understand the effects of marijuana on the brain and health. Marijuana contains tetrahydrocannabinol, or THC, a psychoactive component that leads to several problems including slowing of the reaction time, raising heart rates and also affects the short term memory of the individual.“As is always the case, more research is needed to replicate these effects, to try to understand the mechanisms, and critically, to unearth what additional factors may identify which cannabis-using kids show these effects and which ones don’t,” said Garavan.Data from the National Institute of Drug Abuse has said that 32.6 percent of the tenth graders have used marijuana at least once. On the flip side, 10 states in the United States and the District of Columbia have legalized the recreational use of marijuana. It is also being studied in disease conditions such as pain, muscle spasms, seizures, nausea seen with cancer chemotherapy etc. Source:http://www.jneurosci.org/content/early/2019/01/14/JNEUROSCI.3375-17.2018
Source:Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β‐catenin modulator Annexin A1. EMBO. DOI:10.15252/embr.201847638. By Lois Zoppi, BAMar 5 2019Reviewed by Kate Anderton, B.Sc. (Editor)Findings published by researchers at the Columbia University College of Dental Medicine have identified a common oral bacterium that accelerates colon cancer growth. The discovery could make the detection and treatment of aggressive colon cancers easier.Rost9 | ShutterstockColon cancer is the second largest cause of death in the US. The American Cancer society released figures showing that in 2017 over 95,000 new cases of colon cancer were predicted. The figures also showed that colon cancer incidence rates were “fairly equal” between men (47,700) and women (47,280).“Almost 40% of deaths” from rectal cancer are misclassified as colon cancer on death certificates, reliable statistics on deaths from colon cancer, in particular, are difficult to generate.However, the Colorectal Cancer Facts and Figures 2017-2019 report predicted that an estimated 27,150 men and 23,110 women would die from colorectal cancer in 2017.It is well documented that colon cancer is caused by genetic mutations that build up over a period of decades.Now scientists have been able to compose a more detailed picture, and have shown that approximately a third of colorectal cancers are linked to F. nucleatum bacteria, which occurs in tooth decay.Leader of the study Yiping W. Han Ph.D., professor of microbial sciences at Columbia University College of Dental Medicine and Vagelos College of Physicians and Surgeons said that “mutations are just part of the story,” and that “other factors, including microbes, can also play a role.”Han’s new study builds on previous work by her research team that found that F. nucleatum creates FadA adhesin, a molecule that triggers a signaling pathway in colon cells that has been linked to several cancers.Unusually, the researchers found that FadA adhesion only speeds up the growth of cancerous cells and leaves healthy cells untouched, and colon cancers associated with the bacteria F. nucleatum often become some of the most aggressive.The motivation of this new study was to “find out why F. nucleatum only seemed to interact with the cancerous cells,” Han explained.Using cell cultures, researchers found that protein Annexin A1, responsible for stimulating cancer growth, was not present in noncancerous colon cells. Later tests both in vitro and in mice confirmed that disabling Annexin A1 stopped F. nucleatum bacteria from binding to cancer cells, thus inhibiting their growth.Additionally, it was discovered that F. nucleatum actually increased the production of Annexin A1, which drew in more of the bacteria. We identified a positive feedback loop that worsens the cancer’s progression. […] We propose a two-hit model, where genetic mutations are the first hit. F nucleatum serves as the second hit, accelerating the cancer signaling pathway and speeding tumor growth.”Yiping W. Han, Lead Researcher The National Center for Biotechnology Information has an RNA-sequencing dataset publicly available, which includes information from 466 patients with primary colon cancer.Researchers studied this dataset and found a positive correlation between higher Annexin A1 expression and poorer prognoses, but made no distinctions between sex, age, or the cancer stage or grade.The researchers are now looking for ways to develop Annexin A1 as a biomarker for more aggressive cancers. They also hope that this research will lead to the development of new treatments for colon cancer, among others, using Annexin A1 as a potential target for the new treatments.