Flu vaccine makers get HHS funds to prepare for pandemic

first_imgJun 20, 2007 (CIDRAP News) – Federal health officials last week announced the awarding of contracts totaling $132.5 million to help two vaccine producers get ready to start churning out vaccines in the event of a flu pandemic.The Department of Health and Human Services (HHS) awarded $77.4 million to Sanofi Pasteur and $55.1 million to MedImmune Inc. to retrofit existing vaccine production facilities and keep them in ready condition for 2 years to produce pandemic flu vaccines, with an option to extend the time to 5 years.The goal is that when the retrofitting is done, the facilities together will be capable of producing about 100 million doses of a pandemic vaccine within 6 months of the start of a pandemic, according to Marc Wolfson, a spokesman for HHS’s Office of the Assistant Secretary for Preparedness and Response (formerly the Office of Public Health Emergency Preparedness).That amount represents about 16% of the HHS goal of having enough domestic capacity to make 600 million doses of pandemic flu vaccine—enough for 300 million people—within 6 months after a pandemic hits, Wolfson told CIDRAP News.The renovations also will equip the two companies to produce prepandemic vaccines year-round, HHS said. Currently production of prepandemic vaccines is limited to the 3 months each year when facilities are not tied up with making seasonal flu vaccines, HHS officials said.The HHS contracts call for the two companies to maintain “warm base operations” in the renovated facilities for 2 years, meaning they will not be shut down. The contracts include options for another 3 years of warm-base operations, which would require more money, the agency said.Sanofi Pasteur, located in Swiftwater, Pa., has been the leading producer of seasonal flu vaccine for the US market in recent years. MedImmune, based in Gaithersburg, Md., makes the nasal-spray seasonal flu vaccine FluMist, which uses a live, attenuated virus.Sanofi makes the only prepandemic H5N1 flu vaccine licensed so far by the Food and Drug Administration. HHS has stockpiled the equivalent of 14.5 million 90-microgram doses of the vaccine, according to Wolfson. That’s enough for about 7.25 million people at two doses each. HHS has a goal of stockpiling enough prepandemic flu vaccine for 20 million people.Wolfson said the current US annual production capacity for prepandemic flu vaccines is 16.5 million doses. Besides Sanofi, he said, GlaxoSmithKline and Novartis are also making prepandemic H5N1 vaccines for the US stockpile. Both companies also market seasonal flu vaccines in the United States.Sanofi is building a new flu vaccine plant in Swiftwater and hopes to have it completed in time for the 2008-09 flu season, company spokeswoman Patty Tomski told CIDRAP News. The company will contribute about $25 million to the renovation of its existing plant scheduled under the HHS contract.”The contract covers costs for design, retrofit and the maintenance of the facilities at a state of readiness so the company can switch to pandemic influenza vaccine manufacture at the HHS’s request,” the company said in a news release. Tomski said the plant will be able to start producing a pandemic vaccine at any time of year.The retrofitting is expected to be completed in late 2010, according to Tomski. The renovated plant will use the conventional production method of growing flu viruses in eggs, she reported.With the renovation, the company expects to maintain the plant’s existing production capacity of about 50 million doses a year, Tomski said. The new plant is designed to add capacity for another 100 million doses of seasonal flu vaccine annually.MedImmune will contribute about $14 million to the retrofitting of its facilities under the HHS contract, the company said in a news release.The work will affect MedImmune’s manufacturing and testing facilities in Santa Clara and Mountain View, Calif.; its blending, filling, packaging, and warehousing facilities in Philadelphia and Salem, Pa.; and a storage and distribution center in Louisville, Ky., according to company spokeswoman Karen Lancaster. As part of the renovation, she said, facilities will be expanded to maintain capacity for making seasonal flu vaccines.MedImmune uses an egg-based system to make its intranasal vaccine. The same approach will be used to make pandemic vaccines, though the company is developing a cell-based production system, Lancaster said.See also:Jun 14 HHS news releasehttp://www.hhs.gov/news/press/2007pres/06/20070614a.htmlJun 14 Sanofi news releaseJun 14 MedImmune news releaselast_img read more

Continue reading

Arsenal’s Sokratis Papastathopoulos thinks it’ll be easier to defend against Liverpool than Burnley

first_img Unai Emery reacts to Arsenal’s 2-1 win over BurnleyTo view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Play VideoLoaded: 0%0:00Progress: 0%PlayMuteCurrent Time 0:00/Duration Time 7:01FullscreenUnai Emery reacts to Arsenal’s 2-1 win over Burnleyhttps://metro.co.uk/video/unai-emery-reacts-arsenals-2-1-win-burnley-1987794/This is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Liverpool are being tipped to launch another title tilt this season, but Sokratis believes his partnership with Luiz will be a force to be reckoned with in the Premier League.‘I have known him for a lot of years,’ Sokratis said of Luiz.‘He also speaks some Greek and is a very good guy. Advertisement Liverpool have a dangerous front three (Picture: Getty)‘If they are on good day and you are having a bad day, it is hard. In the end, we know that it is difficult and we respect Liverpool a lot.AdvertisementAdvertisement‘But I think the best [way] is to go and play our style of game. We will see what happens.’Arsenal will have David Luiz at their disposal at Anfield, a player very familiar with Liverpool after two previous spells with Chelsea. Arsenal earned a 2-1 win over Burnley in their last game (Picture: Getty)Sokratis Papastathopoulos has risked the wrath of Liverpool fans after suggesting the Reds will be easier to defend against than Burnley.Arsenal have two wins from two Premier League games this season, including a 2-1 victory over Burnley in their most recent match.Unai Emery takes his side to Anfield on Saturday and after a tough game against Burnley, Sokratis believes defending against Liverpool will not be as difficult.‘It is a different game. Maybe it is more easy, because you don’t have to fight a lot – but they also play football,’ he said.ADVERTISEMENT Coral BarryMonday 19 Aug 2019 6:49 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link524Shares David Luiz has joined Arsenal’s defensive ranks (Picture: Rex Features)‘I am happy also that we took a player like him, with experience.‘When I was in Dortmund I played with Hummels, who has the same style as David. It was also a very good partnership and it is very good (now with Luiz).‘It was his first game, it is important that we won and we can go from here.’MORE: Arsenal preparing incentive-based contract offer to keep Pierre-Emerick Aubameyang at the EmiratesMore: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man City Comment Advertisement Arsenal’s Sokratis Papastathopoulos thinks it’ll be easier to defend against Liverpool than Burnleylast_img read more

Continue reading